[STATS] Etude sur 200 patients

[V2F]

Etude portant sur 200 patients suivis pendant 4 ans:

Sexe masculin: 62,5%
Race blanche: 93%
KC bilatéral : 88,5%
KC de forme familiale : 5%
Asthme : 23%
Eczéma : 14%
Rhume des foins : 30%
Port de lentilles de contact avant le diagnostic : 9%
Frottements oculaires intensifs : 48%
Epaisseur moyenne des cornées inférieure à 0,480mm (Pachymétrie) au départ : 56%
Epaisseur moyenne des cornées inférieure à 0,480mm (Pachymétrie) 4 ans plus tard : 77%
Aucune lésion cornéenne : 15%

-------------------------------------------------------------------------------------

1Department of Ophthalmology, Ninewells Hospital and Medical School, Dundee, Scotland, UK.

AimTo investigate and correlate the corneal, refractive, topographic and familial characteristics of a large cohort with keratoconus.MethodsProspective observational study of 200 consecutive patients presenting with keratoconus during the 4 year-period 1997-2000. Subjects were examined at enrolment and at a final review. Data were collected on demographic characteristics, referral route, symptoms, refractive correction, eye rubbing, family history, medical history, slit-lamp biomicroscopic corneal signs, and computerized corneal topography.ResultsMean age at enrolment was 30.9+/-10.4 (range, 12.2-72) years (N=200, 62.5% male, 93% white Caucasian) with a 5% family history of keratoconus. Atopic diseases included asthma (23%), eczema (14%), and hay fever (30%). Only 9% wore contact lenses before referral. Mean follow-up was 1004 days +/-282 (range, 390-1335) and 9.7+/-8.9 (range, 1.1-60) years from diagnosis. The mean simulated K1 corneal power at enrolment was 51.74+/-5.36 (range, 42.59-67.32) D and 88.5% exhibited bilateral keratoconus. Fifty-three (15%) topographically confirmed cones exhibited no clinical corneal signs at presentation. At enrollment, 56% had a pachymetry <0.480 mm increasing to 77% at final review. Forty-eight percent of subjects reported significant eye rubbing and there was a highly statistically significant difference (two sample t-test P=0.018) between keratoconus and control groups. TMS-2 axial corneal power was strongly associated with corneal scarring and age at diagnosis. The size of the scarring effect was 2.2 D (95% confidence interval (CI) 1.34, 3.06).ConclusionsThis study provides an overview of a large population with keratoconus highlighting presenting features and clinical and topographic progression over a 4 year-period.Eye advance online publication, 19 January 2007; doi:10.1038/sj.eye.6702692.
PMID: 17237755 [PubMed - as supplied by publisher]